Exploration of imidazole and imidazopyridine dimers as anticancer agents: Design, synthesis, and structure-activity relationship study.

Meenakshisundaram, Sangeetha; Manickam, Manoj; Pillaiyar, Thanigaimalai

Meenakshisundaram, Sangeetha; Manickam, Manoj; Pillaiyar, Thanigaimalai.

Affiliation

Meenakshisundaram S; Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India.
Manickam M; Polymer Engineering Laboratory, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu, India.
Pillaiyar T; Department of Pharmaceutical and Medicinal Chemistry, PharmaCenter Bonn, Pharmaceutical Institute, University of Bonn, Bonn, Germany.

Arch Pharm (Weinheim) ; 352(12): e1900011, 2019 Dec.

Article in En | MEDLINE | ID: mdl-31596021

Subject(s)

Antineoplastic Agents/chemical synthesis; Drug Design; Imidazoles/chemical synthesis; Mammary Neoplasms, Experimental/drug therapy; Protein Multimerization/drug effects; Pyridines/chemical synthesis; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; Molecular Structure; Pyridines/chemistry; Pyridines/pharmacology; Rats; Structure-Activity Relationship; Treatment Outcome

Key words

Schiff base dimers; anticancer activity; bis-imidazoles; bis-imidazopyridines; cytotoxicity studies

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Drug Design / Protein Multimerization / Imidazoles / Mammary Neoplasms, Experimental / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Arch Pharm (Weinheim) Year: 2019 Document type: Article Affiliation country: India Country of publication: Germany

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