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Preoperative skin antisepsis using chlorhexidine may reduce surgical wound infections in lower limb trauma surgery when compared to povidone-iodine - a prospective randomized trial.
Ritter, Benedikt; Herlyn, Philipp Karl Ewald; Mittlmeier, Thomas; Herlyn, Anica.
Affiliation
  • Ritter B; Department of Trauma, Orthopaedic, Plastic and Hand Surgery, Augsburg University Medicine, Augsburg, Germany.
  • Herlyn PKE; Department of Trauma, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany.
  • Mittlmeier T; Department of Trauma, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany.
  • Herlyn A; Department of Trauma, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany. Electronic address: anica.herlyn@med.uni-rostock.de.
Am J Infect Control ; 48(2): 167-172, 2020 02.
Article in En | MEDLINE | ID: mdl-31604621
BACKGROUND: For the prevention of surgical wound infections (SSIs), local microorganism counts can be lowered by skin antisepsis prior to surgical incisions. Until now, it has been unclear which antiseptic is the most effective. METHODS: This prospective randomized trial analyzed the efficacy of 2 frequently used agents in the reduction of postoperative wound complication rates after aseptic trauma surgery on the lower leg and foot. In the study, 279 consecutive participants were randomized; 112 received surgical skin preparations using chlorhexidine (CHX) (ChloraPrep; Becton Dickinson, Franklin Lakes, NJ) and 167 received preparations with povidone-iodine (PVP-I) (Braunoderm; B. Braun Melsungen AG, Melsungen, Germany). Primary clinical endpoints were SSIs and wound healing disorders (WHDs) within 6 months after surgery. Secondary outcome variables included demographic and perioperative risk factors for SSIs. RESULTS: Rates of WHDs and SSIs were significantly higher in the PVP-I treatment group, which experienced 9 SSIs and 12 WHDs (n = 21; 12.6%), compared to the CHX treatment group, which had 2 SSIs and 3 WHDs (n = 5; 4.5%) (P = .022). Perioperative risk factors for WHDs were obesity and longer surgery time, whereas SSIs were increased in participants with cardiovascular diseases and suction drainage. Logistic regression analysis showed that the odds of complications of wound healing were 3.5 times higher for PVP-I than for CHX (odds ratio = 3.5; 95% confidence interval, 1.1-11.2; P = .032). CONCLUSIONS: Preoperative skin antisepsis for trauma surgery of the lower leg and foot using CHX led to significantly fewer complications of wound healing when compared to PVP-I.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Povidone-Iodine / Chlorhexidine / Antisepsis / Anti-Infective Agents, Local Type of study: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Am J Infect Control Year: 2020 Document type: Article Affiliation country: Germany Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Povidone-Iodine / Chlorhexidine / Antisepsis / Anti-Infective Agents, Local Type of study: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Am J Infect Control Year: 2020 Document type: Article Affiliation country: Germany Country of publication: United States