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In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval.
Kambayashi, Ryuichi; Hagiwara-Nagasawa, Mihoko; Goto, Ai; Chiba, Koki; Izumi-Nakaseko, Hiroko; Naito, Atsuhiko T; Matsumoto, Akio; Sugiyama, Atsushi.
Affiliation
  • Kambayashi R; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Hagiwara-Nagasawa M; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Goto A; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Chiba K; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Izumi-Nakaseko H; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Naito AT; Division of Cellular Physiology, Department of Physiology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Matsumoto A; Department of Aging Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
  • Sugiyama A; Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo 143-8540, Japan.
J Vet Med Sci ; 81(12): 1735-1739, 2019 Dec 18.
Article in En | MEDLINE | ID: mdl-31611491
ABSTRACT
Correction formulae of QT interval were developed for the halothane-anesthetized microminipigs by adopting atrial pacing (n=5), which were compared with Bazett's and Fridericia's formulae for humans, and Van de Water's one for dogs. The correction formulae QTc=QT-0.2072 (RR-750) as linear and QTc=QT/(RR/750)0.4007 as non-linear equations, were developed for microminipigs. These formulae can better correct the QT interval of the microminipigs compared with each of the conventional ones for humans and dogs. Moreover, analysis of the slope constant α values indicates that the rate-dependent change in the ventricular repolarization period of microminipig may better mimic that of humans than that of dogs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swine, Miniature / Cardiac Pacing, Artificial / Heart Rate Limits: Animals / Female / Humans / Male Language: En Journal: J Vet Med Sci Journal subject: MEDICINA VETERINARIA Year: 2019 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swine, Miniature / Cardiac Pacing, Artificial / Heart Rate Limits: Animals / Female / Humans / Male Language: En Journal: J Vet Med Sci Journal subject: MEDICINA VETERINARIA Year: 2019 Document type: Article Affiliation country: Japan