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Therapeutic failure after regimen with artemether-lumefantrine combination therapy: a report of three cases in Benin City, Nigeria.
Ebohon, Osamudiamen; Irabor, Francis; Ebohon, Linda Osahon; Omoregie, Ehimwenma Sheena.
Affiliation
  • Ebohon O; Michael and Cecilia Ibru University, Department of Biochemistry, Agbarha-Otor, Delta State, Nigeria.
  • Irabor F; Michael and Cecilia Ibru University, Department of Biochemistry, Agbarha-Otor, Delta State, Nigeria.
  • Ebohon LO; Bethel Faith Medical Centre, Benin City, Edo State, Nigeria.
  • Omoregie ES; University of Benin, Faculty of Life Sciences, Department of Biochemistry, Benin City, Edo State, Nigeria.
Rev Soc Bras Med Trop ; 52: e20190163, 2019.
Article in En | MEDLINE | ID: mdl-31618306
ABSTRACT
Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization for the treatment of uncomplicated malaria. Currently, there appears to be a downward trend in the efficacy of ACT in some parts of sub-Saharan Africa because some patients have been positive for Plasmodium parasite 3 days after artemether-lumefantrine treatment. We reported three cases of possible parasite resistance to artemether-lumefantrine therapy. All subjects had complete parasite clearance when treated with other antimalarial drugs. This observation necessitates the urgent need to re-evaluate artemether-lumefantrine medication in Nigeria since it is one of the most commonly used ACT drug.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Artemether, Lumefantrine Drug Combination / Antimalarials Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Rev Soc Bras Med Trop Year: 2019 Document type: Article Affiliation country: Nigeria
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Malaria, Falciparum / Artemether, Lumefantrine Drug Combination / Antimalarials Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Rev Soc Bras Med Trop Year: 2019 Document type: Article Affiliation country: Nigeria