Recent advances from metabolomics and lipidomics application in alzheimer's disease inspiring drug discovery.
Expert Opin Drug Discov
; 15(3): 319-331, 2020 03.
Article
in En
| MEDLINE
| ID: mdl-31619081
ABSTRACT
Introduction:
Although age is a major risk factor for Alzheimer's disease (AD), it is not an inevitable consequence of aging nor is it exclusively an old-age disease. Several other major risk factors for AD are strongly associated with metabolism and include lack of exercise, obesity, diabetes, high blood pressure and cholesterol, over-consumption of alcohol and depression in addition to low educational level, social isolation, and cognitive inactivity. Approaches for Alzheimer prevention and treatment through manipulation of metabolism and utilization of active metabolites have great potential either as a primary or secondary treatment avenue or as a preventative strategy in high-risk individuals.Areas covered This review outlines the current knowledge concerning the relationship between AD and metabolism and the novel treatments attempting to correct changes in AD patients determined through metabolomics or lipidomic analyses.Expert opinion Metabolites are one of the main driving factors and indicators of AD and can offer many possible avenues for prevention and treatment. However, with the highly interconnected effects of metabolites and metabolism, as well as the many different routes for metabolism dysfunction, successful treatment would have to include the correction of metabolic errors as well as errors in transport and metabolite processing in order to affect and revert AD progression.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Discovery
/
Metabolomics
/
Alzheimer Disease
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Aged
/
Animals
/
Humans
Language:
En
Journal:
Expert Opin Drug Discov
Year:
2020
Document type:
Article
Affiliation country:
Canada
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM