Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.

Lee, Lingaku; Ramos-Alvarez, Irene; Ito, Tetsuhide; Jensen, Robert T

Lee, Lingaku; Ramos-Alvarez, Irene; Ito, Tetsuhide; Jensen, Robert T.

Affiliation

Lee L; Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA. frkn505@gmail.com.
Ramos-Alvarez I; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan. frkn505@gmail.com.
Ito T; Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA. irene.ramosalvarez@nih.gov.
Jensen RT; Neuroendocrine Tumor Centra, Fukuoka Sanno Hospital, International University of Health and Welfare 3-6-45 Momochihama, Sawara-Ku, Fukuoka 814-0001, Japan. itopapa@kouhoukai.or.jp.

Int J Mol Sci ; 20(20)2019 Oct 16.

Article in En | MEDLINE | ID: mdl-31623145

Subject(s)

Gastrins/biosynthesis; Proton Pump Inhibitors/therapeutic use; Stomach Diseases/drug therapy; Stomach Diseases/etiology; Zollinger-Ellison Syndrome/complications; Zollinger-Ellison Syndrome/metabolism; Animals; Carcinoma, Neuroendocrine; Chronic Disease; Gastrinoma/metabolism; Humans; Proton Pump Inhibitors/adverse effects; Risk Factors; Stomach Diseases/metabolism; Time Factors; Treatment Outcome

Key words

MEN1; PPI; gastric carcinoid; gastrinoma; hypergastrinemia; neuroendocrine tumor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Diseases / Gastrins / Zollinger-Ellison Syndrome / Proton Pump Inhibitors Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2019 Document type: Article Affiliation country: United States Country of publication: Switzerland

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