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Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.
Yamamoto, Keisuke; Tamura, Tomohiro; Nakamura, Rina; Hosoe, Shintaro; Matsubara, Masahiro; Nagata, Keiko; Kodaira, Hiroshi; Uemori, Takeshi; Takahashi, Yuichi; Suzuki, Michihiko; Saito, Jun-Ichi; Ueno, Kimihisa; Shuto, Satoshi.
Affiliation
  • Yamamoto K; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. Electronic address: keisuke.yamamoto.fn@kyowakirin.com.
  • Tamura T; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Nakamura R; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Hosoe S; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Matsubara M; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Nagata K; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Kodaira H; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Uemori T; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Takahashi Y; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Suzuki M; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Saito JI; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Ueno K; Fuji Research Park, R&D Division, Kyowa Kirin, 1188, Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, Japan.
  • Shuto S; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan; Center for Research and Education on Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. Electronic address: shu@pharm.hokudai.ac.jp.
Bioorg Med Chem ; 27(22): 115122, 2019 11 15.
Article in En | MEDLINE | ID: mdl-31623970
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: PPAR gamma / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: PPAR gamma / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom