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Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus.
Jono, Misato; Kinehara, Yuhei; Utsu, Yoshihiko; Tamura, Yoshiro; Koseto, Masahiro; Murakami, Teruaki; Uota, Akifumi; Ninomiya, Ryusuke; Komo, Satoshi; Sumitani, Satoru; Sato, Bunzo; Kasayama, Soji; Tachibana, Isao.
Affiliation
  • Jono M; Department of Medicine, Nippon Life Hospital, Japan.
  • Kinehara Y; Department of Medicine, Nippon Life Hospital, Japan.
  • Utsu Y; Department of Medicine, Nippon Life Hospital, Japan.
  • Tamura Y; Department of Medicine, Nippon Life Hospital, Japan.
  • Koseto M; Department of Medicine, Nippon Life Hospital, Japan.
  • Murakami T; Department of Medicine, Nippon Life Hospital, Japan.
  • Uota A; Department of Medicine, Nippon Life Hospital, Japan.
  • Ninomiya R; Department of Medicine, Nippon Life Hospital, Japan.
  • Komo S; Department of Medicine, Nippon Life Hospital, Japan.
  • Sumitani S; Department of Medicine, Nippon Life Hospital, Japan.
  • Sato B; Department of Medicine, Nippon Life Hospital, Japan.
  • Kasayama S; Department of Medicine, Nippon Life Hospital, Japan.
  • Tachibana I; Department of Medicine, Nippon Life Hospital, Japan.
Intern Med ; 59(4): 569-572, 2020 Feb 15.
Article in En | MEDLINE | ID: mdl-31666468
The patient was a 73-year-old woman with lung adenocarcinoma and systemic lupus erythematosus (SLE) who was treated with pembrolizumab. After six cycles of pembrolizumab, she developed symptoms suggestive of neuropsychiatric SLE, such as resting tremor, confusional state, depression, mood disorder, and anxiety disorder. In addition, her cerebrospinal fluid level of interleukin-6 was elevated. Her symptoms resolved one month after the discontinuation of pembrolizumab. This is the first report of neuropsychiatric symptoms in a patient with lung cancer and SLE on immune checkpoint blockade therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Mood Disorders / Antibodies, Monoclonal, Humanized / Antineoplastic Agents, Immunological / Adenocarcinoma of Lung / Lupus Erythematosus, Systemic Limits: Aged / Female / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2020 Document type: Article Affiliation country: Japan Country of publication: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Mood Disorders / Antibodies, Monoclonal, Humanized / Antineoplastic Agents, Immunological / Adenocarcinoma of Lung / Lupus Erythematosus, Systemic Limits: Aged / Female / Humans Language: En Journal: Intern Med Journal subject: MEDICINA INTERNA Year: 2020 Document type: Article Affiliation country: Japan Country of publication: Japan