A dithiocarbamate-based H<sub>2</sub>O<sub>2</sub>-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy.

Pan, Qingqing; Zhang, Boya; Peng, Xinyu; Wan, Shiyu; Luo, Kui; Gao, Wenxia; Pu, Yuji; He, Bin

A dithiocarbamate-based H₂O₂-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy.

Pan, Qingqing; Zhang, Boya; Peng, Xinyu; Wan, Shiyu; Luo, Kui; Gao, Wenxia; Pu, Yuji; He, Bin.

Affiliation

Pan Q; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. yjpu@scu.edu.cn.

Chem Commun (Camb) ; 55(92): 13896-13899, 2019 Nov 14.

Article in En | MEDLINE | ID: mdl-31675022

ABSTRACT

Here, we report the rational design of a H2O2-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(ii) to form Cu(DTC)2 with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity to disulfiram.

Subject(s)

Hydrogen Peroxide/chemistry; Prodrugs/chemistry; Thiocarbamates/chemistry; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Cell Survival/drug effects; Copper/chemistry; Disulfiram/pharmacology; Female; Humans; Hydrogen Peroxide/metabolism; Mice; Mice, Inbred BALB C; Microscopy, Confocal; NIH 3T3 Cells; Neoplasms/drug therapy; Neoplasms/pathology; Oxidative Stress/drug effects; Prodrugs/pharmacology; Prodrugs/therapeutic use; Thiocarbamates/pharmacology; Thiocarbamates/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiocarbamates / Prodrugs / Hydrogen Peroxide Limits: Animals / Female / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: China Country of publication: United kingdom

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