A highly sensitive sensor based on a computer-designed magnetic molecularly imprinted membrane for the determination of acetaminophen.
Biosens Bioelectron
; 148: 111819, 2020 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-31678825
ABSTRACT
In this paper, a sensor based on a magnetic surface molecularly imprinted membrane (MMIP) was prepared for the highly sensitive and selective determination of acetaminophen (AP). Before the experiment, the appropriate functional monomers and solvents required for the polymer were screened, and the molecular electrostatic potentials (MEPs) were calculated by the DFT/B3LYP/6-31 + G method. MMIP with high recognition of AP was synthesized based on Fe3O4@SiO2nanoparticles (NPs) with excellent core-shell structure. Next, a carbon paste electrode (CPE) was filled with a piece of neodymium-iron-boron magnet to make magnetic electrode (MCPE), and MMIP/MCPE sensor was obtained by attaching a printed polymer to the surface of the electrode under the strong magnetic. Due to the stable molecular structure of the electrode surface, the sensor is highly effective and accurate for detection of AP using DPV. The DPV response of the sensor exhibited a linear dependence on the concentration of AP from 6â¯×â¯10-8 to 5â¯×â¯10-5â¯molâ¯L-1 and 5â¯×â¯10-5 to 2â¯×â¯10-4â¯molâ¯L-1, with a detection limit based on the lower linear range of 1.73â¯×â¯10-8â¯molâ¯L-1(S/Nâ¯=â¯3). When used for determination of AP in actual samples, the recovery of the sensor to the sample was 95.80-103.76%, and the RSD was 0.78%-3.05%.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymers
/
Analgesics, Non-Narcotic
/
Molecular Imprinting
/
Electrochemical Techniques
/
Magnets
/
Acetaminophen
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Biosens Bioelectron
Journal subject:
BIOTECNOLOGIA
Year:
2020
Document type:
Article