Adriamycin, aclacinomycin and thepirubicin intracardiac distribution examined by fluorescence microscopy.
Chemioterapia
; 7(3): 179-83, 1988 Jun.
Article
in En
| MEDLINE
| ID: mdl-3168073
ABSTRACT
Male Wistar rats received adriamycin, aclacinomycin or thepirubicin at a dose of 4 mg/kg b.w. by slow infusion. Cardiac tissue sections were examined by fluorescence microscopy to evaluate the distribution of the three anthracyclines. The nuclei regularly exhibited a stronger coloring with respect to the cytoplasm for all three drugs. Adriamycin cytoplasm fluoresced intensely, unlike aclacinomycin and thepirubicin. Our results indicate a lower uptake of these last two molecules into cardiac tissue, thus suggesting a different pharmacokinetic profile which might account for their lower cardiotoxicity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aclarubicin
/
Doxorubicin
/
Antibiotics, Antineoplastic
/
Myocardium
Limits:
Animals
Language:
En
Journal:
Chemioterapia
Year:
1988
Document type:
Article
Affiliation country:
Italy