The transcription factor Twist1 in the distal nephron but not in macrophages propagates aristolochic acid nephropathy.

Ren, Jiafa; Rudemiller, Nathan P; Wen, Yi; Lu, Xiaohan; Privratsky, Jamie R; Crowley, Steven D

Ren, Jiafa; Rudemiller, Nathan P; Wen, Yi; Lu, Xiaohan; Privratsky, Jamie R; Crowley, Steven D.

Affiliation

Ren J; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Rudemiller NP; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Wen Y; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Lu X; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Privratsky JR; Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Crowley SD; Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Durham VA Medical Center, Durham, North Carolina, USA. Electronic address: steven.d.crowley@duke.edu.

Kidney Int ; 97(1): 119-129, 2020 01.

Article in En | MEDLINE | ID: mdl-31685313

Subject(s)

Kidney Tubules, Distal/pathology; Macrophages/immunology; Nephritis, Interstitial/immunology; Renal Insufficiency, Chronic/immunology; Twist-Related Protein 1/metabolism; Animals; Apoptosis/drug effects; Apoptosis/immunology; Aristolochic Acids/toxicity; Coculture Techniques; Disease Models, Animal; Epithelial Cells; Female; Fibrosis; Gene Knockdown Techniques; Hepatitis A Virus Cellular Receptor 1/metabolism; Humans; Kidney Tubules, Distal/cytology; Kidney Tubules, Distal/immunology; Kidney Tubules, Distal/metabolism; Lipocalin-2/metabolism; Macrophages/metabolism; Mice; Mice, Transgenic; Nephritis, Interstitial/chemically induced; Nephritis, Interstitial/pathology; Primary Cell Culture; Renal Insufficiency, Chronic/chemically induced; Renal Insufficiency, Chronic/pathology; Twist-Related Protein 1/genetics; Up-Regulation/drug effects; Up-Regulation/immunology

Key words

chronic kidney disease; distal tubule; macrophages

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Twist-Related Protein 1 / Kidney Tubules, Distal / Macrophages / Nephritis, Interstitial Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Kidney Int Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google