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A nanoscale metal-organic framework for combined photodynamic and starvation therapy in treating breast tumors.
Guan, Qun; Zhou, Le-Le; Li, Yan-An; Dong, Yu-Bin.
Affiliation
  • Guan Q; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. yananli@sdnu.edu.cn yubindong@sdnu.edu.cn.
Chem Commun (Camb) ; 55(99): 14898-14901, 2019 Dec 10.
Article in En | MEDLINE | ID: mdl-31687688
We demonstrate herein an effective cascade reaction for combined photodynamic and starvation therapy in treating breast tumors based on a photosensitizer and CO prodrug decorated NMOF. The PDT-induced ROS can further trigger CO release, and the high antitumor efficiency derived from both 1O2 and CO is well confirmed by in vitro assays and in vivo trials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Boron Compounds / Photosensitizing Agents / Nanostructures / Metal-Organic Frameworks Limits: Female / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Boron Compounds / Photosensitizing Agents / Nanostructures / Metal-Organic Frameworks Limits: Female / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom