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Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins.
Mediani, L; Guillén-Boixet, J; Alberti, S; Carra, S.
Affiliation
  • Mediani L; Centre for Neuroscience and Nanotechnology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Guillén-Boixet J; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
  • Alberti S; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
  • Carra S; Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Biotechnology Center (BIOTEC), Dresden, Germany.
Mol Cell Oncol ; 6(6): e1415624, 2019.
Article in En | MEDLINE | ID: mdl-31693723
ABSTRACT
We uncovered a role for nucleoli and PML-bodies as phase-separated protein quality control organelles that compartmentalize protein quality control factors and misfolded proteins for their efficient clearance. Failure to dispose misfolded proteins converts nucleoli and PML-bodies into a solid state that immobilizes ubiquitin, limiting its recycling for genome integrity maintenance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Cell Oncol Year: 2019 Document type: Article Affiliation country: Italy
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Cell Oncol Year: 2019 Document type: Article Affiliation country: Italy