Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells.

Anderson, George; Rodriguez, Moses; Reiter, Russel J

Anderson, George; Rodriguez, Moses; Reiter, Russel J.

Affiliation

Anderson G; CRC Scotland & London, London E16 6JE, UK.
Rodriguez M; Departments of Neurology & Immunology, Mayo Clinic College of Medicine & Science, Rochester, MN 55905, USA.
Reiter RJ; Department Cellular and Structural Biology, Uni Texas Health Science Center, San Antonio, TX 78229, USA.

Int J Mol Sci ; 20(21)2019 Nov 05.

Article in En | MEDLINE | ID: mdl-31694154

Subject(s)

Ceramides/immunology; Gastrointestinal Microbiome; Melatonin/immunology; Multiple Sclerosis/immunology; Orexins/immunology; Platelet Activation; Animals; Butyrates/immunology; Chronobiology Disorders/immunology; Chronobiology Disorders/microbiology; Chronobiology Disorders/pathology; Chronobiology Disorders/physiopathology; Humans; Immunity, Cellular; Inflammation/immunology; Inflammation/microbiology; Inflammation/pathology; Inflammation/physiopathology; Mitochondria/immunology; Mitochondria/pathology; Multiple Sclerosis/microbiology; Multiple Sclerosis/pathology; Multiple Sclerosis/physiopathology; Neuroglia/immunology; Neuroglia/pathology

Key words

circadian; gut dysbiosis; gut permeability; immune-inflammation; melatonin; mitochondria; multiple sclerosis; orexin; platelets; treatment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Platelet Activation / Ceramides / Orexins / Gastrointestinal Microbiome / Melatonin / Multiple Sclerosis Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2019 Document type: Article Affiliation country: United kingdom

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