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Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis.
Liu, Xiu-Xiu; Yang, Lin; Shao, Ling-Xiao; He, Yang; Wu, Gang; Bao, Yu-Huan; Lu, Nan-Nan; Gong, Dong-Mei; Lu, Ya-Ping; Cui, Tian-Tian; Sun, Ning-He; Chen, Dan-Yang; Shi, Wei-Xing; Fukunaga, Kohji; Chen, Hong-Shan; Chen, Zhong; Han, Feng; Lu, Ying-Mei.
Affiliation
  • Liu XX; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China.
  • Yang L; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Shao LX; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • He Y; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
  • Wu G; School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China.
  • Bao YH; Key Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China.
  • Lu NN; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Gong DM; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Lu YP; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Cui TT; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Sun NH; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
  • Chen DY; School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China.
  • Shi WX; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Fukunaga K; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Chen HS; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
  • Chen Z; School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang, China.
  • Han F; Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Lu YM; Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.
J Exp Med ; 217(1)2020 01 06.
Article in En | MEDLINE | ID: mdl-31699822
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Interleukin-8B / Endothelial Cells / Epilepsy / Cyclin-Dependent Kinase 5 / Chemokine CXCL1 / Gliosis Limits: Animals Language: En Journal: J Exp Med Year: 2020 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Interleukin-8B / Endothelial Cells / Epilepsy / Cyclin-Dependent Kinase 5 / Chemokine CXCL1 / Gliosis Limits: Animals Language: En Journal: J Exp Med Year: 2020 Document type: Article Affiliation country: China Country of publication: United States