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The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: A large prospective cohort study.
Jordão, Haydée Wt; McKenna, Gerry; McMenamin, Úna C; Kunzmann, Andrew T; Murray, Liam J; Coleman, Helen G.
Affiliation
  • Jordão HW; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
  • McKenna G; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
  • McMenamin ÚC; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
  • Kunzmann AT; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
  • Murray LJ; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
  • Coleman HG; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
United European Gastroenterol J ; 7(9): 1241-1249, 2019 11.
Article in En | MEDLINE | ID: mdl-31700637
Background: Controversy remains as to whether poor oral health is independently associated with gastrointestinal cancers, due to potential confounding by smoking, alcohol and poor nutrition. The aim of this study was to investigate the association between oral health conditions and gastrointestinal cancer risk. Methods: Data from the large, prospective UK Biobank cohort, which includes n = 475,766 participants, were analysed. Cox proportional hazard models were applied to estimate the relationship between gastrointestinal cancer risk and self-reported poor oral health (defined as painful gums, bleeding gums and/or having loose teeth), adjusting for confounders. Results: During an average six years of follow-up, n = 4069 gastrointestinal cancer cases were detected, of which 13% self-reported poor oral health. Overall, there was no association between self-reported poor oral health and risk of gastrointestinal cancer detected (hazard ratio 0.97, 95% confidence interval 0.88-1.07). In site-specific analysis, an increased risk of hepatobiliary cancers was observed in those with self-reported poor oral health (hazard ratio 1.32, 95% confidence interval 0.95-1.80), which was stronger for hepatocellular carcinoma (hazard ratio 1.75, 95% confidence interval 1.04-2.92). Conclusion: Overall there was no association between self-reported poor oral health and gastrointestinal cancer risk. However, there was a suggestion of an increased risk of hepatobiliary cancer, specifically hepatocellular carcinoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oral Health / Digestive System Neoplasms / Mouth Diseases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: United European Gastroenterol J Year: 2019 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oral Health / Digestive System Neoplasms / Mouth Diseases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: United European Gastroenterol J Year: 2019 Document type: Article Country of publication: United kingdom