Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.

Peters, Finn; Salihoglu, Hazal; Pratsch, Katrin; Herzog, Etienne; Pigoni, Martina; Sgobio, Carmelo; Lichtenthaler, Stefan F; Neumann, Ulf; Herms, Jochen

Peters, Finn; Salihoglu, Hazal; Pratsch, Katrin; Herzog, Etienne; Pigoni, Martina; Sgobio, Carmelo; Lichtenthaler, Stefan F; Neumann, Ulf; Herms, Jochen.

Affiliation

Peters F; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Salihoglu H; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Pratsch K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Herzog E; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Pigoni M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Sgobio C; IINS, UMR 5297, Université Bordeaux, Bordeaux, France.
Lichtenthaler SF; CNRS, IINS, UMR 5297, Bordeaux, France.
Neumann U; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Herms J; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

EMBO J ; 38(23): e102345, 2019 12 02.

Article in En | MEDLINE | ID: mdl-31701556

Subject(s)

Alzheimer Disease/prevention & control; Amyloid Precursor Protein Secretases/physiology; Aspartic Acid Endopeptidases/antagonists & inhibitors; Gene Expression Regulation; Plaque, Amyloid/prevention & control; tau Proteins/antagonists & inhibitors; Alzheimer Disease/etiology; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Amyloid Precursor Protein Secretases/antagonists & inhibitors; Amyloid Precursor Protein Secretases/genetics; Amyloid Precursor Protein Secretases/metabolism; Animals; Aspartic Acid Endopeptidases/genetics; Aspartic Acid Endopeptidases/metabolism; Brain/metabolism; Brain/pathology; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Transgenic; Plaque, Amyloid/etiology; Plaque, Amyloid/metabolism; Plaque, Amyloid/pathology

Key words

BACE1; axonal dystrophies; tau deletion; two-photon in vivo microscopy; ß-amyloid plaque

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Aspartic Acid Endopeptidases / Tau Proteins / Plaque, Amyloid / Amyloid Precursor Protein Secretases / Alzheimer Disease Type of study: Etiology_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: EMBO J Year: 2019 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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