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Phages Enter the Fight against Colorectal Cancer.
Kannen, Vinicius; Parry, Lee; Martin, Francis L.
Affiliation
  • Kannen V; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada. Electronic address: vkc@queensu.ca.
  • Parry L; European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff University, Cardiff, UK.
  • Martin FL; School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.
Trends Cancer ; 5(10): 577-579, 2019 10.
Article in En | MEDLINE | ID: mdl-31706504
ABSTRACT
Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Colorectal Neoplasms / Gastrointestinal Microbiome Limits: Animals / Humans Language: En Journal: Trends Cancer Year: 2019 Document type: Article
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacteriophages / Colorectal Neoplasms / Gastrointestinal Microbiome Limits: Animals / Humans Language: En Journal: Trends Cancer Year: 2019 Document type: Article