Phages Enter the Fight against Colorectal Cancer.
Trends Cancer
; 5(10): 577-579, 2019 10.
Article
in En
| MEDLINE
| ID: mdl-31706504
ABSTRACT
Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteriophages
/
Colorectal Neoplasms
/
Gastrointestinal Microbiome
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Cancer
Year:
2019
Document type:
Article