Isobenzofuranone monomer and dimer derivatives from the mangrove endophytic fungus Epicoccum nigrum SCNU-F0002 possess α-glucosidase inhibitory and antioxidant activity.
Bioorg Chem
; 94: 103407, 2020 01.
Article
in En
| MEDLINE
| ID: mdl-31711768
ABSTRACT
Four new isobenzofuranone monomers, (+)-epicoccone C ((+)-1), (-)-epicoccone C ((-)-1), epicoccone D (2), epicoccone E (3) and one new isobenzofuranone dimer, epicolactone A (4), together with four known related dimers were obtained from the fermentation of an endophytic fungus, Epicoccum nigrum SCNU-F0002, which was isolated from the fresh fruit of the mangrove plant Acanthus ilicifolius L. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. These isolated compounds (1-8) were evaluated for their antioxidant activity and α-glucosidase enzyme inhibitory activity. All of the compounds except 5 exhibited more potent α-glucosidase inhibitory effect than acarbose. Most of the compounds showed superior antioxidant activity with IC50 values ranging from 10.2 to 15.3⯵M than positive control, gallic acid and vitamin C.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ascomycota
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Plant Extracts
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Alpha-Glucosidases
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Fruit
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Fungi
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Antioxidants
Language:
En
Journal:
Bioorg Chem
Year:
2020
Document type:
Article
Affiliation country:
China