Bioactive terpenoid constituents from Eclipta prostrata.
Phytochemistry
; 170: 112192, 2020 Feb.
Article
in En
| MEDLINE
| ID: mdl-31726325
ABSTRACT
Chemical fractionation of the ethanolic extract of Eclipta prostrata yielded a series of unreported terpenoid constituents, including a rare 6/6/6/6-fused tetracyclic triterpenoid, a pentacyclic triterpenoid, two pentacyclic triterpenoid saponins, a diterpenoid and a sesquiterpenoid. Structures were assigned to these compounds on the basis of comprehensive spectroscopic analyses, with the absolute configurations of the tetracyclic triterpenoid, the diterpenoid and the sesquiterpenoid being determined via explanation of electronic circular dichroism data. Screening of these isolates in an array of bioassays revealed antibacterial, cytotoxic and α-glucosidase inhibitory activities for selective compounds. Of particular interest, the tetracyclic triterpenoid showed very strong inhibition against α-glucosidase with an IC50 of 0.82⯱â¯0.18⯵M, being 103-fold as active as the positive control acarbose.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Terpenes
/
Plant Extracts
/
Eclipta
/
Phytochemicals
/
Glycoside Hydrolase Inhibitors
/
Anti-Bacterial Agents
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Phytochemistry
Year:
2020
Document type:
Article
Affiliation country:
China