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Polyketides from the endolichenic fungus Eupenicillium javanicum and their anti-inflammatory activities.
Xu, Ke; Li, Gang; Zhu, Rongxiu; Xie, Fei; Li, Yuelan; Yang, Wenjing; Xu, Lintao; Shen, Tao; Zhao, Zuntian; Lou, Hongxiang.
Affiliation
  • Xu K; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Li G; Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
  • Zhu R; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.
  • Xie F; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Li Y; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Yang W; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Xu L; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Shen T; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.
  • Zhao Z; College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Jinan 250014, People's Republic of China.
  • Lou H; Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China. Electronic address: louhongxiang@sdu.edu.cn.
Phytochemistry ; 170: 112191, 2020 Feb.
Article in En | MEDLINE | ID: mdl-31731236
ABSTRACT
Seven undescribed polyketides javanicols A-E, 5-epi-citreoviridin and 5-epi-isocitreoviridin, together with five known compounds, were isolated from the endolichenic fungus Eupenicillium javanicum. The structures of these polyketides were determined by means of extensive spectroscopic analyses, electronic circular dichroism (ECD) calculations and gauge-independent atomic orbital (GIAO) NMR shift calculations. These compounds were evaluated for potential anti-inflammatory activity against LPS-activated RAW 264.7 cells. Javanicol E and (+)-terrein displayed moderate inhibitory effects on NO production, with IC50 values of 17.00 and 13.46 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Eupenicillium / Polyketides / Nitric Oxide Limits: Animals Language: En Journal: Phytochemistry Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Eupenicillium / Polyketides / Nitric Oxide Limits: Animals Language: En Journal: Phytochemistry Year: 2020 Document type: Article