Facile fabrication of a novel 3D rose like lanthanum doped zirconia decorated reduced graphene oxide nanosheets: An efficient electro-catalyst for electrochemical reduction of futuristic anti-cancer drug salinomycin during pharmacokinetic study.
Biosens Bioelectron
; 150: 111849, 2020 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-31733999
ABSTRACT
An innovative electrochemical nanoprobe, for analysis of salinomycin (SAL), was proposed. The nanoprobe based on decoration of glassy carbon electrode (GCE) with 3D rose like La3+@ ZrO2 supported on reduced graphene oxide (RGO) nanosheets. The 3D rose like La3+@ ZrO2 was synthesized via sintering process. The successful decoration of 3D rose like La3+@ ZrO2 on the surface of RGO was characterized using different spectroscopic and analytical techniques. The obtained voltammetric results confirmed the good electrochemical performance of 3D rose like La3+@ ZrO2 in terms of lower peak potential (Epc) and higher cathodic current (Ipc). Moreover, the modified nanoprobe showed wide linearity range (0.34-115â¯×â¯10-8â¯M), lower detection limit (0.11â¯×â¯10-8â¯M) and higher selectivity. Besides, the nanocomposite showed good applicability for analysis of SAL in biological fluids and during pharmacokinetic evaluation in rabbit plasma. The obtained results opens a new venue for the determination of futuristic drug, SAL, during pharmacokinetic and pharmacodynamics studies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrans
/
Biosensing Techniques
/
Electrochemical Techniques
/
Graphite
Limits:
Humans
Language:
En
Journal:
Biosens Bioelectron
Journal subject:
BIOTECNOLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Saudi Arabia