Site-specific acylation of a bacterial virulence regulator attenuates infection.

Zhang, Zhenrun J; Pedicord, Virginia A; Peng, Tao; Hang, Howard C

Zhang, Zhenrun J; Pedicord, Virginia A; Peng, Tao; Hang, Howard C.

Affiliation

Zhang ZJ; Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY, USA.
Pedicord VA; Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY, USA.
Peng T; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
Hang HC; Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY, USA.

Nat Chem Biol ; 16(1): 95-103, 2020 01.

Article in En | MEDLINE | ID: mdl-31740807

Subject(s)

Fatty Acids/metabolism; Gene Expression Regulation, Bacterial; Genomic Islands; Salmonella typhimurium/metabolism; Virulence; Animals; Arginine/chemistry; Bacterial Proteins/metabolism; Binding Sites; Butyrates/chemistry; CRISPR-Cas Systems; Genome, Bacterial; Genomics; Lysine/chemistry; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Proteomics/methods; Salmonella typhimurium/pathogenicity; Trans-Activators/metabolism; Virulence Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Salmonella typhimurium / Virulence / Gene Expression Regulation, Bacterial / Genomic Islands / Fatty Acids Limits: Animals Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2020 Document type: Article Affiliation country: United States

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