TZAP Mutation Leads to Poor Prognosis of Patients with Breast Cancer .
Medicina (Kaunas)
; 55(11)2019 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-31752241
ABSTRACT
Background and Objectives:
ZBTB48 is a telomere-associated factor that has been renamed as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Materials andMethods:
We analyzed the TZAP mutation in 128 breast carcinomas (BCs). In addition, its association with telomere length was investigated.Results:
The TZAP mutation (c.1272 G > A, L424L) was found in 7.8% (10/128) of the BCs and was associated with the N0 stage. BCs with the TZAP mutation had longer telomeres than those without this mutation. Survival analysis showed that the TZAP mutation resulted in poorer overall survival.Conclusions:
These results suggest that the TZAP mutation is a possible prognostic marker in BC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Breast Neoplasms
/
DNA-Binding Proteins
/
Mutation
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Medicina (Kaunas)
Journal subject:
MEDICINA
Year:
2019
Document type:
Article
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND