Identification of small molecule inhibitors of human COQ7.
Bioorg Med Chem
; 28(1): 115182, 2020 01 01.
Article
in En
| MEDLINE
| ID: mdl-31753803
ABSTRACT
Given that the associated clinical manifestations of ubiquinone (UQ, or coenzyme Q) deficiency diseases are highly heterogeneous and complicated, effective new research tools for UQ homeostasis studies are awaited. We set out to develop human COQ7 inhibitors that interfere with UQ synthesis. Systematic structure-activity relationship development starting from a screening hit compound led to the identification of highly potent COQ7 inhibitors that did not disturb physiological cell growth of human normal culture cells. These new COQ7 inhibitors may serve as useful tools for studying the balance between UQ supplementation pathways de novo UQ synthesis and extracellular UQ uptake.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitochondrial Proteins
/
Enzyme Inhibitors
/
Small Molecule Libraries
/
Mixed Function Oxygenases
/
Antineoplastic Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2020
Document type:
Article
Affiliation country:
Japan