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Mechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy: What Is New?
Komlósi, Zsolt István; Kovács, Nóra; Sokolowska, Milena; van de Veen, Willem; Akdis, Mübeccel; Akdis, Cezmi A.
Affiliation
  • Komlósi ZI; Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad Sqr. 4, Budapest 1089, Hungary. Electronic address: komlosi.zsolt@med.semmelweis-univ.hu.
  • Kovács N; Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad Sqr. 4, Budapest 1089, Hungary; Lung Health Hospital, Munkácsy Mihály Str. 70, Törökbálint 2045, Hungary.
  • Sokolowska M; Swiss Institute of Allergy and Asthma Research (SIAF), Hermann-Burchard Strasse 9, Davos Wolfgang CH7265, Switzerland; Christine Kühne - Center for Allergy Research and Education, Hermann-Burchard Strasse 1, Davos Wolfgang CH7265, Switzerland.
  • van de Veen W; Swiss Institute of Allergy and Asthma Research (SIAF), Hermann-Burchard Strasse 9, Davos Wolfgang CH7265, Switzerland; Christine Kühne - Center for Allergy Research and Education, Hermann-Burchard Strasse 1, Davos Wolfgang CH7265, Switzerland.
  • Akdis M; Swiss Institute of Allergy and Asthma Research (SIAF), Hermann-Burchard Strasse 9, Davos Wolfgang CH7265, Switzerland; Christine Kühne - Center for Allergy Research and Education, Hermann-Burchard Strasse 1, Davos Wolfgang CH7265, Switzerland.
  • Akdis CA; Swiss Institute of Allergy and Asthma Research (SIAF), Hermann-Burchard Strasse 9, Davos Wolfgang CH7265, Switzerland; Christine Kühne - Center for Allergy Research and Education, Hermann-Burchard Strasse 1, Davos Wolfgang CH7265, Switzerland.
Immunol Allergy Clin North Am ; 40(1): 1-14, 2020 02.
Article in En | MEDLINE | ID: mdl-31761112
ABSTRACT
Allergen immunotherapy (AIT) is considered to be the only treatment option with the promise of healing and induction of long-lasting allergen tolerance, persisting even after discontinuation of therapy. Despite a more than 100-year-long history, still only a minority of patients are being treated with AIT. Substantial developments took place in the last decade to overcome problems in standardization, efficacy, safety, high costs, long duration of treatment; and new guidelines have also been implemented. Major advancements in the understanding of AIT mechanisms with the focus on recent findings of subcutaneous and sublingual AIT have been summarized.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desensitization, Immunologic / T-Lymphocytes, Regulatory / B-Lymphocytes, Regulatory / Hypersensitivity Type of study: Guideline / Health_economic_evaluation Limits: Animals / Humans Language: En Journal: Immunol Allergy Clin North Am Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desensitization, Immunologic / T-Lymphocytes, Regulatory / B-Lymphocytes, Regulatory / Hypersensitivity Type of study: Guideline / Health_economic_evaluation Limits: Animals / Humans Language: En Journal: Immunol Allergy Clin North Am Journal subject: ALERGIA E IMUNOLOGIA Year: 2020 Document type: Article