The moonlighting peroxiredoxin-glutaredoxin in Neisseria meningitidis binds plasminogen via a C-terminal lysine residue and contributes to survival in a whole blood model.

Aljannat, Mahab A K; Oldfield, Neil J; Albasri, Hibah M; Dorrington, Louise K G; Ohri, Radhica L; Wooldridge, Karl G; Turner, David P J

Aljannat, Mahab A K; Oldfield, Neil J; Albasri, Hibah M; Dorrington, Louise K G; Ohri, Radhica L; Wooldridge, Karl G; Turner, David P J.

Affiliation

Aljannat MAK; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Oldfield NJ; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Albasri HM; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Dorrington LKG; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Ohri RL; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Wooldridge KG; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.
Turner DPJ; School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK. Electronic address: david.turner@nottingham.ac.uk.

Microb Pathog ; 139: 103890, 2020 Feb.

Article in En | MEDLINE | ID: mdl-31765768

Subject(s)

Glutaredoxins/metabolism; Host-Pathogen Interactions; Meningococcal Infections/metabolism; Meningococcal Infections/microbiology; Neisseria meningitidis/physiology; Peroxiredoxins/metabolism; Plasminogen/metabolism; Enzyme-Linked Immunosorbent Assay; Glutaredoxins/chemistry; Glutaredoxins/genetics; Humans; Hydrogen Peroxide/metabolism; Meningococcal Infections/diagnosis; Meningococcal Infections/mortality; Mutation; Peroxiredoxins/chemistry; Peroxiredoxins/genetics; Plasminogen/chemistry; Prognosis; Protein Binding; Protein Interaction Domains and Motifs

Key words

Neisseria meningitidis; Pathogenesis; Peroxiredoxin; Plasminogen; Protein moonlighting; Whole blood model

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen / Glutaredoxins / Peroxiredoxins / Host-Pathogen Interactions / Meningococcal Infections / Neisseria meningitidis Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Microb Pathog Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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