Kinetics of cytokine receptor trafficking determine signaling and functional selectivity.

Martinez-Fabregas, Jonathan; Wilmes, Stephan; Wang, Luopin; Hafer, Maximillian; Pohler, Elizabeth; Lokau, Juliane; Garbers, Christoph; Cozzani, Adeline; Fyfe, Paul K; Piehler, Jacob; Kazemian, Majid; Mitra, Suman; Moraga, Ignacio

Martinez-Fabregas, Jonathan; Wilmes, Stephan; Wang, Luopin; Hafer, Maximillian; Pohler, Elizabeth; Lokau, Juliane; Garbers, Christoph; Cozzani, Adeline; Fyfe, Paul K; Piehler, Jacob; Kazemian, Majid; Mitra, Suman; Moraga, Ignacio.

Affiliation

Martinez-Fabregas J; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Wilmes S; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Wang L; Department Computer Science, Purdue University, West Lafayette, United States.
Hafer M; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Pohler E; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Lokau J; Department of Pathology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Garbers C; Department of Pathology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Cozzani A; INSERM UMR-S-11721, Centre de Recherche Jean-Pierre Aubert (JPARC), Institut pour la Recherche sur le Cancer de Lille (IRCL), Université de Lille, Lille, France.
Fyfe PK; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.
Piehler J; Department of Biology, University of Osnabrück, Osnabrück, Germany.
Kazemian M; Department Computer Science, Purdue University, West Lafayette, United States.
Mitra S; INSERM UMR-S-11721, Centre de Recherche Jean-Pierre Aubert (JPARC), Institut pour la Recherche sur le Cancer de Lille (IRCL), Université de Lille, Lille, France.
Moraga I; Division of Cell Signaling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

Elife ; 82019 11 27.

Article in En | MEDLINE | ID: mdl-31774398

Subject(s)

Cytokine Receptor gp130/chemistry; Interleukin-6/chemistry; STAT1 Transcription Factor/metabolism; T-Lymphocytes, Regulatory/metabolism; Th1 Cells/metabolism; Th17 Cells/metabolism; Binding Sites; Cell Differentiation; Cloning, Molecular; Cytokine Receptor gp130/genetics; Cytokine Receptor gp130/metabolism; Endosomes/chemistry; Endosomes/metabolism; Gene Expression; HeLa Cells; Humans; Interleukin-6/genetics; Interleukin-6/metabolism; Kinetics; Models, Molecular; Phosphorylation; Primary Cell Culture; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Engineering/methods; Protein Interaction Domains and Motifs; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; STAT1 Transcription Factor/genetics; STAT3 Transcription Factor/genetics; STAT3 Transcription Factor/metabolism; Signal Transduction; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology; Th1 Cells/cytology; Th1 Cells/immunology; Th17 Cells/cytology; Th17 Cells/immunology

Key words

bias signaling; cytokine engineering; cytokine signaling; endosomal traffic; functional pleiotropy; human; immunology; inflammation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-6 / T-Lymphocytes, Regulatory / Th1 Cells / STAT1 Transcription Factor / Cytokine Receptor gp130 / Th17 Cells Type of study: Prognostic_studies Language: En Journal: Elife Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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