Hemophagocytic lymphohistiocytosis in a patient with glioblastoma: a case report.
CNS Oncol
; 8(4): CNS45, 2019 12 01.
Article
in En
| MEDLINE
| ID: mdl-31777271
ABSTRACT
Adult onset hemophagocytic lymphohistiocytosis (HLH) is a rare condition, usually secondary to either a precipitating infective or hematologic malignancy. We present a case of Epstein-Barr virus associated HLH in a 55-year-old female receiving treatment for a glioblastoma (GBM). It is possible that HLH is under recognized, as patients with GBM often have features of a nonspecific systemic inflammatory response syndrome, multiorgan failure and cognitive decline. A high index of suspicion and increased awareness can help improve timeliness of diagnosis. Therapeutically, Epstein-Barr virus associated HLH in patients with solid organ malignancy poses significant challenges. An individualized, multidisciplinary approach is essential when managing adult-onset HLH and providers will need to be mindful of the high mortality rate despite treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Glioblastoma
/
Lymphohistiocytosis, Hemophagocytic
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
CNS Oncol
Year:
2019
Document type:
Article
Affiliation country:
United States