Binding of anticancer drug adriamycin to parallel G-quadruplex DNA [d-(TTAGGGT)]<sub>4</sub> comprising human telomeric DNA leads to thermal stabilization: A multiple spectroscopy study.

Raje, Shailja; Pandav, Kumud; Barthwal, Ritu

Binding of anticancer drug adriamycin to parallel G-quadruplex DNA [d-(TTAGGGT)]₄ comprising human telomeric DNA leads to thermal stabilization: A multiple spectroscopy study.

Raje, Shailja; Pandav, Kumud; Barthwal, Ritu.

Affiliation

Raje S; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India.
Pandav K; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India.
Barthwal R; Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India.

J Mol Recognit ; 33(2): e2815, 2020 02.

Article in En | MEDLINE | ID: mdl-31793724

Subject(s)

DNA/genetics; Doxorubicin/chemistry; G-Quadruplexes/drug effects; Telomere/genetics; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Base Sequence/drug effects; Circular Dichroism; DNA/chemistry; DNA/drug effects; Doxorubicin/pharmacology; Humans; Telomerase/chemistry; Telomere/drug effects

Key words

absorption and fluorescence; anticancer drug adriamycin; circular dichroism; nuclear magnetic resonance; telomeric G-quadruplex DNA; thermal denaturation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Doxorubicin / Telomere / G-Quadruplexes Limits: Humans Language: En Journal: J Mol Recognit Journal subject: BIOLOGIA MOLECULAR Year: 2020 Document type: Article Affiliation country: India

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