Altered levels of complement components associated with non-immediate drug hypersensitivity reactions.

Wang, Feng; Huang, Liping; Yu, Junfeng; Zang, Dandan; Ye, Liangping; Zhu, Qixing

Wang, Feng; Huang, Liping; Yu, Junfeng; Zang, Dandan; Ye, Liangping; Zhu, Qixing.

Affiliation

Wang F; Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Huang L; Key Laboratory of Dermatology, Ministry of Education, Hefei, China.
Yu J; Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, China.
Zang D; Department of Dermatology, Fifth Affiliated Hospital of Chengdu City, Chengdu, China.
Ye L; Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, China.
Zhu Q; Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China.

J Immunotoxicol ; 17(1): 1-9, 2020 12.

Article in En | MEDLINE | ID: mdl-31795786

Subject(s)

Complement System Proteins/metabolism; Drug Eruptions/immunology; Skin/pathology; Stevens-Johnson Syndrome/immunology; Adult; Aged; Biomarkers/analysis; Biomarkers/metabolism; Case-Control Studies; Complement Factor H; Complement System Proteins/analysis; Complement System Proteins/genetics; Down-Regulation/immunology; Drug Eruptions/pathology; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Profiling; Humans; Immunohistochemistry; Male; Middle Aged; RNA, Messenger/analysis; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Skin/immunology; Stevens-Johnson Syndrome/pathology; Up-Regulation/immunology; Young Adult

Key words

Complement; StevensJohnson syndrome (SJS); hypersensitivity; maculopapular exanthema (MPE); toxic epidermal necrolysis (TEN)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Complement System Proteins / Stevens-Johnson Syndrome / Drug Eruptions Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Immunotoxicol Journal subject: ALERGIA E IMUNOLOGIA / TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: China Country of publication: United kingdom

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