Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1&#945; pathway in diabetic kidney.

Akhtar, Safia; Siragy, Helmy M

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney.

Akhtar, Safia; Siragy, Helmy M.

Affiliation

Akhtar S; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.
Siragy HM; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America.

PLoS One ; 14(12): e0225728, 2019.

Article in En | MEDLINE | ID: mdl-31800607

Subject(s)

AMP-Activated Protein Kinases/metabolism; Diabetic Nephropathies/etiology; Diabetic Nephropathies/metabolism; Mitochondria/metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism; Receptors, Cell Surface/metabolism; Signal Transduction; Sirtuin 1/metabolism; Adenosine Triphosphate/metabolism; Animals; Biomarkers; Biopsy; Cell Line; DNA Copy Number Variations; Diabetes Mellitus, Experimental; Diabetic Nephropathies/pathology; Disease Models, Animal; Gene Expression; Immunohistochemistry; Male; Mesangial Cells/metabolism; Mesangial Cells/pathology; Mice; Mitochondria/genetics; NF-E2-Related Factor 1/genetics; NF-E2-Related Factor 1/metabolism; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics; RNA Interference; Receptors, Cell Surface/genetics; Prorenin Receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Cell Surface / Diabetic Nephropathies / AMP-Activated Protein Kinases / Sirtuin 1 / Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / Mitochondria Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

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