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Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness.
Hulpia, Fabian; Mabille, Dorien; Campagnaro, Gustavo D; Schumann, Gabriela; Maes, Louis; Roditi, Isabel; Hofer, Anders; de Koning, Harry P; Caljon, Guy; Van Calenbergh, Serge.
Affiliation
  • Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000, Gent, Belgium.
  • Mabille D; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
  • Campagnaro GD; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
  • Schumann G; Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland.
  • Maes L; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
  • Roditi I; Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland.
  • Hofer A; Department of Medical Biochemistry and Biophysics, Umeå University, 901 87, Umeå, Sweden.
  • de Koning HP; College of Medical, Veterinary and Life Sciences, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
  • Caljon G; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, Belgium.
  • Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, 9000, Gent, Belgium. Serge.VanCalenbergh@UGent.be.
Nat Commun ; 10(1): 5564, 2019 12 05.
Article in En | MEDLINE | ID: mdl-31804484
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma brucei brucei / Trypanosomiasis, African / Tubercidin / Protozoan Proteins / Deoxyadenosines / Nucleoside Transport Proteins Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Belgium Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma brucei brucei / Trypanosomiasis, African / Tubercidin / Protozoan Proteins / Deoxyadenosines / Nucleoside Transport Proteins Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Belgium Country of publication: United kingdom