A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase.

Giancotti, Gilda; Rigo, Ilaria; Pasqualetto, Gaia; Young, Mark T; Neyts, Johan; Rocha-Pereira, Joana; Brancale, Andrea; Ferla, Salvatore; Bassetto, Marcella

Giancotti, Gilda; Rigo, Ilaria; Pasqualetto, Gaia; Young, Mark T; Neyts, Johan; Rocha-Pereira, Joana; Brancale, Andrea; Ferla, Salvatore; Bassetto, Marcella.

Affiliation

Giancotti G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Rigo I; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Pasqualetto G; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Young MT; Cardiff School of Biosciences, Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, UK.
Neyts J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Rocha-Pereira J; KU Leuven - Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.
Ferla S; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK. ferlas1@cardiff.ac.uk.
Bassetto M; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff, King Edward VII Avenue, Cardiff, CF103NB, UK.

Sci Rep ; 9(1): 18413, 2019 12 05.

Article in En | MEDLINE | ID: mdl-31804593

Subject(s)

Antiviral Agents/chemical synthesis; Norovirus/drug effects; Oxazoles/chemical synthesis; Pyrimidines/chemical synthesis; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Sulfonamides/chemical synthesis; Thiophenes/chemical synthesis; Viral Proteins/antagonists & inhibitors; Animals; Antiviral Agents/pharmacology; Binding Sites; Drug Design; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Gene Expression; Humans; Mice; Molecular Docking Simulation; Norovirus/enzymology; Norovirus/genetics; Norovirus/growth & development; Oxazoles/pharmacology; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Pyrimidines/pharmacology; RAW 264.7 Cells; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/metabolism; Structure-Activity Relationship; Substrate Specificity; Sulfonamides/pharmacology; Thiophenes/pharmacology; Viral Proteins/chemistry; Viral Proteins/metabolism; Virus Replication/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Oxazoles / Pyrimidines / Sulfonamides / Thiophenes / Viral Proteins / RNA-Dependent RNA Polymerase / Norovirus Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: United kingdom

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