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Design, Synthesis and Discovery of N,N'-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication.
Spizzichino, Sharon; Mattedi, Giulio; Lauder, Kate; Valle, Coralie; Aouadi, Wahiba; Canard, Bruno; Decroly, Etienne; Kaptein, Suzanne J F; Neyts, Johan; Graham, Carl; Sule, Zakary; Barlow, David J; Silvestri, Romano; Castagnolo, Daniele.
Affiliation
  • Spizzichino S; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Mattedi G; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory Affiliated to Instituto Pasteur Italia - Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy.
  • Lauder K; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Valle C; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Aouadi W; AFMB, CNRS, Aix-Marseille University UMR 7257, Case 925, 163 Avenue de Luminy, 13288, Marseille Cedex 09, France.
  • Canard B; AFMB, CNRS, Aix-Marseille University UMR 7257, Case 925, 163 Avenue de Luminy, 13288, Marseille Cedex 09, France.
  • Decroly E; AFMB, CNRS, Aix-Marseille University UMR 7257, Case 925, 163 Avenue de Luminy, 13288, Marseille Cedex 09, France.
  • Kaptein SJF; AFMB, CNRS, Aix-Marseille University UMR 7257, Case 925, 163 Avenue de Luminy, 13288, Marseille Cedex 09, France.
  • Neyts J; Department of Microbiology, Immunology and Transplantation Rega Institute for Medical Research Laboratory of Virology and Chemotherapy, KU Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium.
  • Graham C; Department of Microbiology, Immunology and Transplantation Rega Institute for Medical Research Laboratory of Virology and Chemotherapy, KU Leuven, Minderbroedersstraat 10, 3000, Leuven, Belgium.
  • Sule Z; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Barlow DJ; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Silvestri R; School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 9NH, UK.
  • Castagnolo D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory Affiliated to Instituto Pasteur Italia - Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185, Roma, Italy.
ChemMedChem ; 15(4): 385-390, 2020 02 17.
Article in En | MEDLINE | ID: mdl-31805205
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Urea / Virus Replication / Drug Discovery / Zika Virus / Methyltransferases Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2020 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Urea / Virus Replication / Drug Discovery / Zika Virus / Methyltransferases Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2020 Document type: Article Affiliation country: United kingdom