Inhibition of CXCL1-CXCR2 axis ameliorates cisplatin-induced acute kidney injury by mediating inflammatory response.

Liu, Peng; Li, Xinxiu; Lv, Weixing; Xu, Zhaojun

Liu, Peng; Li, Xinxiu; Lv, Weixing; Xu, Zhaojun.

Affiliation

Liu P; Department of Intensive Care Unit, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Li X; Department of Experimental Medical Science, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo, China. Electronic address: 24520141153445@stu.xmu.edu.cn.
Lv W; Department of Intensive Care Unit, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
Xu Z; Department of Intensive Care Unit, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China. Electronic address: 13957837168@163.com.

Biomed Pharmacother ; 122: 109693, 2020 Feb.

Article in En | MEDLINE | ID: mdl-31812015

Subject(s)

Acute Kidney Injury/pathology; Chemokine CXCL1/metabolism; Cisplatin/pharmacology; Receptors, Interleukin-8B/metabolism; Sulfonamides/pharmacology; Acute Kidney Injury/chemically induced; Acute Kidney Injury/drug therapy; Animals; Chemokine CXCL1/deficiency; Cytokines/metabolism; Inflammation/drug therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; NF-kappa B/metabolism; Receptors, Interleukin-8B/deficiency; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

Acute kidney injury; CXCL1; CXCR2; Cisplatin; Inflammation; NF-κB; P38

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Cisplatin / Receptors, Interleukin-8B / Chemokine CXCL1 / Acute Kidney Injury Type of study: Prognostic_studies Limits: Animals Language: En Journal: Biomed Pharmacother Year: 2020 Document type: Article Affiliation country: China Country of publication: France

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