Diastereo- and Enantioselective Synthesis of Quaternary α-Amino Acid Precursors by Copper-Catalyzed Propargylation.
Org Lett
; 21(24): 9985-9989, 2019 12 20.
Article
in En
| MEDLINE
| ID: mdl-31820655
ABSTRACT
A diastereo- and enantioselective propargylic substitution reaction between propargylic carbonates and α-substituted nitroacetates catalyzed by a Cu-pybox complex is described. This method allows the preparation of a series of non-proteinogenic quaternary α-amino acid precursors featuring two contiguous stereogenic centers and a terminal alkyne moiety in high yields with good to excellent diastereo- and enantioselectivities in most cases. The propargylated adducts were elaborated into a diverse set of quaternary α-amino acid derivatives.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pargyline
/
Copper
/
Amino Acids
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2019
Document type:
Article