Synthesis of ß-cyclodextrin-PEG-G molecules to delay tumor growth and application of ß-cyclodextrin-PEG-G aggregates as drug carrier.
Carbohydr Polym
; 229: 115478, 2020 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-31826440
ABSTRACT
The clinical use of many chemotherapeutic drugs is considerably greatly limited due to their serious side effects. This problem can be solved by using a low-toxic or nontoxic drug carrier that exhibits excellent performance in entrapping chemotherapeutic drugs. Accordingly, ß-cyclodextrin-PEG-guanosine (ß-CD-PEG-G) molecule was first synthesized. The molecules can self-assemble into negatively charged spherical aggregates (called ß-CD-PEG-G aggregates) that can stably exist in an aqueous solution and entrap doxorubicin (Dox) to form ß-CD-PEG-G-Dox nanomedicine. Dox encapsulation efficiency is approximately 79 ± 6.3%. Dox from ß-CD-PEG-G-Dox nanomedicine exhibits sustained release and pH responsiveness. Cell and animal experiments showed that ß-CD-PEG-G-Dox nanomedicine could effectively induce cancer cell apoptosis to exert antitumor activity. Unexpectively, the animal experiment and tissue sections demonstrated that ß-CD-PEG-G aggregates exhibit certain antitumor activity that could delay the tumor growth. Therefore, the ß-CD-PEG-G molecule has high potential as a drug carrier candidate.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethylene Glycols
/
Drug Carriers
/
Beta-Cyclodextrins
/
Guanosine
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Carbohydr Polym
Year:
2020
Document type:
Article