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The correlation between adiponectin and FGF9 in depression disorder.
Wang, Xiao-Qing; Li, Wei-Hui; Tang, Ya-Hui; Wu, Li-Feng; Zeng, Gui-Rong; Wang, Yu-Hong; Cheng, Ze-Neng; Jiang, De-Jian.
Affiliation
  • Wang XQ; XiangYa Pharmacy School, Central South University, Changsha 410083, China; Hunan Center for Safety Evaluation and Research of Drugs & Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410013, China.
  • Li WH; Department of Psychiatry, The Second XiangYa Hospital of Central South University, Changsha 410011, China.
  • Tang YH; Hunan Center for Safety Evaluation and Research of Drugs & Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410013, China.
  • Wu LF; Hunan Center for Safety Evaluation and Research of Drugs & Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410013, China.
  • Zeng GR; Hunan Center for Safety Evaluation and Research of Drugs & Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410013, China.
  • Wang YH; Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
  • Cheng ZN; XiangYa Pharmacy School, Central South University, Changsha 410083, China. Electronic address: chengzn@csu.edu.cn.
  • Jiang DJ; Hunan Center for Safety Evaluation and Research of Drugs & Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410013, China; Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China. Electro
Brain Res ; 1729: 146596, 2020 02 15.
Article in En | MEDLINE | ID: mdl-31836511
ABSTRACT
Adiponectin (ADPN) and fibroblast growth factor 9 (FGF9) has been reported as anti-depressive and pro-depressive factor, respectively. However, it is unknown whether there is directly interaction between ADPN and FGF9 in depression. The present study aims to investigate the correlation between ADPN and FGF9 in depression disorder. Firstly, the decreased level of ADPN and the increased level of FGF9 in plasma of depressive patients compared with non-depressive subjects were observed. Furthermore, these is a significant negative correlation between the ratio of ADPN to FGF9 and the total score of Hamilton Depression Scale in total investigated subjects. The similar changes of ADPN and FGF9 were also observed in elder adiponectin gene knockout (Adipo-/-) mice with an increasing trend to depressive-like behaviors. Secondly, the decreasing level of ADPN and increasing level of FGF9 in plasma and hippocampus tissues were observed in chronic unpredictable mild stress (CUMS)-induced depression in ICR mice with significant depressive-like behaviors and hippocampus damage, which attenuated by injection of recombinant ADPN or FGF9 antibody into lateral ventricle. In Adipo-/- mice, injection of FGF9 antibody into lateral ventricle also attenuated CUMS-induced depressivelike behaviors. The protein expression of FGF receptor 3 (FGFR3), the main receptor of FGF9, was significantly down-regulated in hippocampus tissues of CUMS-treated mice, which could be attenuated by treatment with either recombinant ADPN or anti-FGF9. In summary, the present results suggest that ADPN maybe a key negative regulator of FGF9/FGFR3 in depressive disorder and the dysfunction of ADPN-FGF9 pathway plays a key role in stress-induced depression.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mice, Knockout / Depression / Adiponectin / Fibroblast Growth Factor 9 Limits: Animals / Humans / Male Language: En Journal: Brain Res Year: 2020 Document type: Article Affiliation country: China Publication country: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mice, Knockout / Depression / Adiponectin / Fibroblast Growth Factor 9 Limits: Animals / Humans / Male Language: En Journal: Brain Res Year: 2020 Document type: Article Affiliation country: China Publication country: HOLANDA / HOLLAND / NETHERLANDS / NL / PAISES BAJOS / THE NETHERLANDS