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Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.
Indra, Radek; Pompach, Petr; Vavrová, Katarína; Jáklová, Katerina; Heger, Zbynek; Adam, Vojtech; Eckschlager, Tomás; Kopecková, Katerina; Arlt, Volker Manfred; Stiborová, Marie.
Affiliation
  • Indra R; Department of Biochemistry, Faculty of Science, Charles University, Albertov, 2030, 128 40 Prague 2, Czech Republic.
  • Pompach P; Department of Biochemistry, Faculty of Science, Charles University, Albertov, 2030, 128 40 Prague 2, Czech Republic.
  • Vavrová K; Department of Biochemistry, Faculty of Science, Charles University, Albertov, 2030, 128 40 Prague 2, Czech Republic.
  • Jáklová K; Department of Biochemistry, Faculty of Science, Charles University, Albertov, 2030, 128 40 Prague 2, Czech Republic.
  • Heger Z; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic.
  • Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300 Brno, Czech Republic.
  • Eckschlager T; Department of Pediatric Hematology and Oncology, 2nd Medical Faculty, Charles University and University Hospital Motol, 150 06 Prague, Czech Republic.
  • Kopecková K; Department of Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague 5, Czech Republic.
  • Arlt VM; Department of Analytical, Environmental and Forensic Sciences, MRC-PHE Centre for Environment and Health, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
  • Stiborová M; Department of Biochemistry, Faculty of Science, Charles University, Albertov, 2030, 128 40 Prague 2, Czech Republic. Electronic address: stiborov@natur.cuni.cz.
Environ Toxicol Pharmacol ; 74: 103310, 2020 Feb.
Article in En | MEDLINE | ID: mdl-31837525
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygenases / Piperidines / Quinazolines / Cytochrome P-450 Enzyme System / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Environ Toxicol Pharmacol Year: 2020 Document type: Article Affiliation country: Czech Republic Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygenases / Piperidines / Quinazolines / Cytochrome P-450 Enzyme System / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Environ Toxicol Pharmacol Year: 2020 Document type: Article Affiliation country: Czech Republic Country of publication: Netherlands