Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.
Nat Neurosci
; 23(1): 15-20, 2020 01.
Article
in En
| MEDLINE
| ID: mdl-31844313
ABSTRACT
Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dopamine
/
Electron Transport
/
Energy Metabolism
/
Dopaminergic Neurons
/
Monoamine Oxidase
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
United States