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Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Haruwaka, Koichiro; Ikegami, Ako; Tachibana, Yoshihisa; Ohno, Nobuhiko; Konishi, Hiroyuki; Hashimoto, Akari; Matsumoto, Mami; Kato, Daisuke; Ono, Riho; Kiyama, Hiroshi; Moorhouse, Andrew J; Nabekura, Junichi; Wake, Hiroaki.
Affiliation
  • Haruwaka K; Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Ikegami A; Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan.
  • Tachibana Y; Department of Physiological Sciences, The Graduate School for Advanced Study, Hayama, Japan.
  • Ohno N; Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Konishi H; Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Hashimoto A; Department of Anatomy, Division of Histology and Cell Biology, Jichi Medical University, Tochigi, Japan.
  • Matsumoto M; Division of Ultrastructural Research, National Institute for Physiological Sciences, Okazaki, Japan.
  • Kato D; Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ono R; Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Kiyama H; Section of Electron Microscopy, Supportive Center for Brain Research, National Institute for Physiological Sciences, Okazaki, Japan.
  • Moorhouse AJ; Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Nabekura J; Division of System Neuroscience, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Wake H; Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nat Commun ; 10(1): 5816, 2019 12 20.
Article in En | MEDLINE | ID: mdl-31862977
ABSTRACT
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood-brain barrier (BBB) integrity in this process remains unclear. Using simultaneous in vivo imaging, we demonstrated that systemic inflammation induces CCR5-dependent migration of brain resident microglia to the cerebral vasculature. Vessel-associated microglia initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 and make physical contact with endothelial cells. During sustained inflammation, microglia phagocytose astrocytic end-feet and impair BBB function. Our results show microglia play a dual role in maintaining BBB integrity with implications for elucidating how systemic immune-activation impacts neural functions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Cerebrovascular Circulation / Microglia / Endothelial Cells / Lupus Erythematosus, Systemic Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Cerebrovascular Circulation / Microglia / Endothelial Cells / Lupus Erythematosus, Systemic Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2019 Document type: Article Affiliation country: Japan