Research on heterocyclic compounds. XXIV. Antiinflammatory activity of some imidazo[1,2-c]pyrimidine derivatives.
Res Commun Chem Pathol Pharmacol
; 61(2): 167-83, 1988 Aug.
Article
in En
| MEDLINE
| ID: mdl-3187191
ABSTRACT
A group of four acidic imidazo[1,2-c]pyrimidine derivatives were subjected to a series of tests in vivo in order to assess their pharmacological activity. Antiinflammatory activity was studied by means of the carrageenin-induced paw edema and pleurisy in rats. Hot plate test and writhing induced by acetic acid in mice were employed to evaluate analgesic activity, whereas the yeast-induced hyperthermia in rats was used to study antipyretic activity. The irritative and ulcerogenic action on the rat gastric mucosa was examined at higher doses. The inhibitory activity on the platelet malondialdehyde production was studied in order to obtain information about the mechanism of action of test compounds.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidines
/
Anti-Inflammatory Agents, Non-Steroidal
/
Imidazoles
Limits:
Animals
Language:
En
Journal:
Res Commun Chem Pathol Pharmacol
Year:
1988
Document type:
Article
Affiliation country:
Italy