The Mitotic Apparatus and Kinetochores in Microcephaly and Neurodevelopmental Diseases.
Cells
; 9(1)2019 12 24.
Article
in En
| MEDLINE
| ID: mdl-31878213
ABSTRACT
Regulators of mitotic division, when dysfunctional or expressed in a deregulated manner (over- or underexpressed) in somatic cells, cause chromosome instability, which is a predisposing condition to cancer that is associated with unrestricted proliferation. Genes encoding mitotic regulators are growingly implicated in neurodevelopmental diseases. Here, we briefly summarize existing knowledge on how microcephaly-related mitotic genes operate in the control of chromosome segregation during mitosis in somatic cells, with a special focus on the role of kinetochore factors. Then, we review evidence implicating mitotic apparatus- and kinetochore-resident factors in the origin of congenital microcephaly. We discuss data emerging from these works, which suggest a critical role of correct mitotic division in controlling neuronal cell proliferation and shaping the architecture of the central nervous system.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kinetochores
/
Microcephaly
/
Spindle Apparatus
Limits:
Humans
Language:
En
Journal:
Cells
Year:
2019
Document type:
Article
Affiliation country:
Italy