Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents.
Med Chem
; 17(6): 638-645, 2021.
Article
in En
| MEDLINE
| ID: mdl-31880248
ABSTRACT
OBJECTIVE:
It was interesting to synthesize some new 5-imino-4-thioxoimidazolidin-2- one derivatives with different halogenated and alkylated aromatic substituents at N-(1) and N-(3) and evaluation of their expected antibacterial and antifungal activities.METHODS:
New 5-imino-4-thioxoimidazolidin-2-one derivatives were synthesized through the reaction of different halogenated and alkylated N-arylcyanothioformamides with halogenated and alkylated aryl isocyanates.RESULTS:
5-Imino-4-thioxoimidazolidin-2-ones were obtained in high yields with excellent purity. The activities of imidazolidines as antibacterial and antifungal agents were studied. Some of the imidazolidine derivatives displayed significant antibacterial and antifungal activities.CONCLUSION:
5-Imino-4-thioxoimidazolidin-2-ones were obtained in 77-90% yields with excellent purity. The antibacterial and antifungal activities suggest that some of the imidazole derivatives possess significant antimicrobial activity against B. subtilis, K. pneumonia and C. albicans and moderate activity against S. aureus.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Imidazolidines
/
Anti-Bacterial Agents
/
Antifungal Agents
Language:
En
Journal:
Med Chem
Journal subject:
QUIMICA
Year:
2021
Document type:
Article
Affiliation country:
Egypt