Characterization of an Electronic Corneal Prosthesis System.
Curr Eye Res
; 45(8): 914-920, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-31886728
ABSTRACT
PURPOSE:
Corneal opacity is a leading cause of reversible blindness worldwide. An electronic corneal prosthesis, or intraocular projector, could potentially restore high-quality vision without need for corneal clarity. MATERIALS ANDMETHODS:
Four intraocular projection systems were constructed from commercially available electronic components and encased in biocompatible plastic housing. They were tested for optical properties, biocompatibility, heat dissipation, waterproofing, and accelerated wear. A surgical implantation technique was developed.RESULTS:
Intraocular projectors were produced of a size that can fit within the eye. Their optics produce better than 20/200 equivalent visual acuity. MTT assay demonstrated no cytotoxicity of devices in vitro. Temperature testing demonstrated less than 2°C increase in temperature after 1 h. Three devices lasted over 12 weeks under accelerated wear conditions. Implantation surgery was demonstrated via corneal trephination insertion in a cadaver eye.CONCLUSION:
This is the first study to demonstrate and characterize fully functional intraocular projection systems. This technology has the potential to be an important new tool in the treatment of intractable corneal blindness.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cornea
/
Corneal Opacity
/
Prosthesis Implantation
/
Visual Prosthesis
/
Wearable Electronic Devices
Limits:
Humans
Language:
En
Journal:
Curr Eye Res
Year:
2020
Document type:
Article
Affiliation country:
United States