N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation.
Carbohydr Polym
; 230: 115641, 2020 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-31887884
ABSTRACT
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Carbohydr Polym
Year:
2020
Document type:
Article
Affiliation country:
Italy