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Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Ommer, Johannes; Selfe, Joanna L; Wachtel, Marco; O'Brien, Eleanor M; Laubscher, Dominik; Roemmele, Michaela; Kasper, Stephanie; Delattre, Olivier; Surdez, Didier; Petts, Gemma; Kelsey, Anna; Shipley, Janet; Schäfer, Beat W.
Affiliation
  • Ommer J; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Selfe JL; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Wachtel M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • O'Brien EM; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Laubscher D; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Roemmele M; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Kasper S; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Delattre O; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
  • Surdez D; France INSERM U830, Équipe Labellisé LNCC, PSL Université, SIREDO Oncology Centre, Institut Curie, Paris, France.
  • Petts G; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
  • Kelsey A; Department of Diagnostic Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
  • Shipley J; Sarcoma Molecular Pathology Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Schäfer BW; Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. Beat.schaefer@kispi.uzh.ch.
Cancer Res ; 80(4): 832-842, 2020 02 15.
Article in En | MEDLINE | ID: mdl-31888889
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Oncogene Proteins, Fusion / Rhabdomyosarcoma, Alveolar / Paired Box Transcription Factors / Aurora Kinase A / N-Myc Proto-Oncogene Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Oncogene Proteins, Fusion / Rhabdomyosarcoma, Alveolar / Paired Box Transcription Factors / Aurora Kinase A / N-Myc Proto-Oncogene Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Res Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States