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Mild behavioral impairment is associated with ß-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.
Lussier, Firoza Z; Pascoal, Tharick A; Chamoun, Mira; Therriault, Joseph; Tissot, Cécile; Savard, Mélissa; Kang, Min Su; Mathotaarachchi, Sulantha; Benedet, Andrea L; Parsons, Marlee; Qureshi, Muhammad Naveed Iqbal; Thomas, Émilie M; Shin, Monica; Dion, Laurie-Anne; Massarweh, Gassan; Soucy, Jean-Paul; Tsai, I-Huang; Vitali, Paolo; Ismail, Zahinoor; Rosa-Neto, Pedro; Gauthier, Serge.
Affiliation
  • Lussier FZ; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Pascoal TA; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Chamoun M; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Therriault J; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Tissot C; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Savard M; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Kang MS; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Mathotaarachchi S; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Benedet AL; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Parsons M; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Qureshi MNI; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Thomas ÉM; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Shin M; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Dion LA; Montreal Neurological Institute, Montreal, Quebec, Canada.
  • Massarweh G; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Soucy JP; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Tsai IH; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Vitali P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Ismail Z; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
  • Rosa-Neto P; Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Douglas Hospital, McGill University, Montreal, Quebec, Canada.
  • Gauthier S; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Alzheimers Dement ; 16(1): 192-199, 2020 01.
Article in En | MEDLINE | ID: mdl-31914223
ABSTRACT

INTRODUCTION:

Mild behavioral impairment (MBI) is characterized by the emergence of neuropsychiatric symptoms in elderly persons. Here, we examine the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals.

METHODS:

Ninety-six cognitively normal elderly individuals underwent MRI, [18 F]AZD4694 ß-amyloid-PET, and [18 F]MK6240 tau-PET. MBI was assessed using the MBI Checklist (MBI-C). Pearson's correlations and voxel-based regressions were used to evaluate the relationship between MBI-C score and [18 F]AZD4694 retention, [18 F]MK6240 retention, and gray matter (GM) volume.

RESULTS:

Pearson correlations revealed a positive relationship between MBI-C score and global and striatal [18 F]AZD4694 standardized uptake value ratios (SUVRs). Voxel-based regression analyses revealed a positive correlation between MBI-C score and [18 F]AZD4694 retention. No significant correlations were found between MBI-C score and [18 F]MK6240 retention or GM volume.

CONCLUSION:

We demonstrate for the first time a link between MBI and early AD pathology in a cognitively intact elderly population, supporting the use of the MBI-C as a metric to enhance clinical trial enrolment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Image Processing, Computer-Assisted / Biomarkers / Tau Proteins / Healthy Volunteers / Amyloid Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2020 Document type: Article Affiliation country: Canada
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Image Processing, Computer-Assisted / Biomarkers / Tau Proteins / Healthy Volunteers / Amyloid Type of study: Risk_factors_studies Limits: Aged / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2020 Document type: Article Affiliation country: Canada